Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex.

Transl Psychiatry · 2026 · PMC13338397 · PMID 42103735

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0.0014

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0.0014

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nominally significantp -value = 0.00138actually significant

The CAMK2B gene that regulates CAMKII is a nominally significant DEG in our meta-analysis (wfisher p -value = 0.00138, adj p -value = 0.0619) and is known to interact with the ARC and RAS genes (enriched DEGs), and also ERK/MAPK pathways [ 69 , 84 ].

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