Barely Significant
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Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α-Synuclein and Mediation of Age Effects.

Mov Disord Clin Pract · 2026 · PMC13339541 · PMID 41788046

Europe PMCDOI
1
hedged sentence
0.0200
closest p · 0.4× alpha
0.0200
boldest claim

The sentences

nominally significantP = 0.020actually significant
In combined‐cohort models adjusted for genetic subgroup (Sporadic/LRRK2/GBA/Other), the AD × SAA interaction at the visuospatial endpoint remained nominally significant (eg, JLO‐MSSAE P = 0.020), and leave‐one‐subgroup‐out analyses (dropping LRRK2 or GBA) yielded comparable estimates (JLO scaled measures P ≈ 0.042–0.047), indicating the signal was not driven by a single genetic subgroup despite LRRK2 contributing most SAA‐negative cases.

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