RKER-012, a modified ActRIIB-Fc ligand trap with BMP sparing properties, attenuates pathological features of experimental pulmonary arterial hypertension.

In this study, relative to Nx-Veh, SuHx-Veh had significantly increased expression of E-selectin, Sele [ p = 0.0003] ( Figure 6A ), vascular cell adhesion molecule-, Vcam-1 [ p = 0.0102] ( Figure 6C ), connective tissue growth factor, Ctgf [ p < 0.05] ( Figure 6D ), and osteopontin, Spp1 [ p = 0.0025] ( Figure 6E ), with a strong trend for elevated P-selectin, Slep [ p = 0.0939] ( Figure 6B ).

also in 5,725 other papers

In contrast, SuHx rats treated with RKER-012 had significantly reduced expression of Cd68 [ p = 0.0058] ( Figure 7D ) compared to SuHx-Veh, while a decreasing trend in the expression of Mcp1 [ p = 0.1736] ( Figure 7B ), Il6 [ p = 0.0876] ( Figure 7E ), and Tgfb1 [ p = 0.2156] were observed ( Figure 7C ).

also in 47,180 other papers

Although not statistically significant, non-muscularized [ p = 0.1215] arteries in the SuHx rats treated with RKER-012 showed an increasing trend.

also in 63,971 other papers