Integrated machine learning and multi-omics analysis identifies CYP1B1 as a candidate target of orientin in intervertebral disc degeneration-associated low back pain.

In uncorrected pairwise comparisons, only the proportion of activated NK cells showed a nominally significant difference between the IDD and control groups (raw P = 0.04949).

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In contrast to the AF tissue, analysis of the NP scRNA-seq dataset revealed an overall trend of decreased CYP1B1 expression in disease samples, these data indicate that CYP1B1 expression is dynamically regulated in a cell-type-specific and tissue-specific manner under disease conditions.

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