PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.

Along these same lines, WT-PNPLA3 expressing mice displayed a strong trend ( p = 0.059) for increased left ventricle anterior wall thickness during diastole (LVAWd) post 16 weeks of MASH diet, which was not observed in either GFP or PNPLA3-I148M expressing mice (Fig. 4 F).

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