Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice.

Although two-way ANOVA analysis only indicated a weak trend on the interaction between cohorts over the time points tested (p = 0.0846), Tukey post-hoc analysis showed that Line 15 mice treated with the higher dose of Thiamet-G showed more navigation on the open field as early as after one month (p = 0.0188) and after seven month of treatment (p = 0.0002) ( Figure 4A ).

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Remarkably, 200 mkd of Thiamet-G also strongly and significantly (p < 0.0001) reduced the number of pS129-α-synuclein aggregates ( Figure 3D , E, G) and though a clear trend was observed, a post-hoc analysis did not suggest a significant concentration-dependent effect (Line 15 TMG 500 mkd vs.

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