Although the percentage of CypHer5E + RTECs that ingested one of more apoptotic Jurkat cells did not differ between Elmo1 +/+ and Elmo1 –/– RTECs, we noted a strong trend toward the reduced number of engulfed cells per Elmo1 –/– RTEC (compared to control), as evident by the reduced geometric mean fluorescence index (MFI) of the CypHer5E signal (Fig. 3C ).
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ELMO1 dependent efferocytosis protects from nephrotoxin induced acute kidney injury.
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