Comparative validation of oxidative bisulfite sequencing (oxBS) and chemical-assisted pyridine borane sequencing (CAPS) protocols for locus-specific 5-hydroxymethylcytosine quantification.

Epigenetics Chromatin · 2026 · PMC13352651 · PMID 42010631

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a clear trendno p-value reported

In contrast, oxidation with K 2 RuO 4 showed a clear trend: the longer the bisulfite incubation, the lower were the C/(C + T) ratios, reflecting efficient oxidation of 5hmC to 5fC and subsequent conversion to uracil.

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