Efficacy and safety of rivaroxaban plus aspirin compared with aspirin alone in patients with peripheral arterial disease: a systematic review and meta-analysis.

Ann Med Surg (Lond) · 2026 · PMC13354395 · PMID 42433747

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantP < 0.001actually significant

Inclusion of this trial in a meta-analysis rendered the overall results highly significant ( P < 0.001) and suggests that low-dose aspirin reduces vascular events by 26% and should routinely be considered for PAD patients, including those with type 2 diabetes [ 18 ] .

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failed to reach statistical significanceno p-value reported

In addition, the major amputation (RR: 0.81, P = 0.09) failed to reach statistical significance and was rated as moderate certainty due to the imprecision.

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