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Bridging pathogenesis and therapy in focal segmental glomerulosclerosis: the rise of dual receptor blockade with sparsentan.

Ann Med Surg (Lond) · 2026 · PMC13354399 · PMID 42433793

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Although sparsentan failed to reach statistical significance in the primary efficacy endpoint of reducing eGFR, its main clinical benefit is the meaningful reduction in proteinuria, an important marker for long-term renal outcomes in FSGS [ 1 , 4 ] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.