Mitochondrial DNA mutations drive tumor heterogeneity in papillary thyroid carcinoma.

iScience · 2026 · PMC13355223 · PMID 42436980

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As the sum of mtDNA mutation VAFs increased, tumors showed a significant trend toward a higher immune-to-stromal (I/S) ratio ( p for trend = 0.013; Figures 5 A and S5 ), along with a corresponding increase in immune response gene set scores ( p for trend = 0.005; Figure 5 B).

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