Bench to bedside: is rapamycin headed for the docTOR?

Geroscience · 2026 · PMC13355979 · PMID 42126807

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Although these results align with mouse and human studies suggesting that chronic rapamycin treatment can cause hyperglycemia and hyperlipidemia, this was a very small study, and the between-group comparisons with a placebo control group did not reach statistical significance ( p = 0.07 and 0.12 for A1C and triglyceride changes, respectively).

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