Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

Although the effects of these agents on survival were modest, it is important to note that only one dose was examined, leaving open the possibility of greater effect size using different doses for each of these three agents, as well as for FSK whose suggestive beneficial results did not achieve significance at the dose tested.

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EPI trended toward increased median lifespan of males at all 3 sites, but the effect did not reach statistical significance at any one site (Figure S1A, Table S1b).

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