Muscle-brain crosstalk as a driver of brain health in aging.

Geroscience · 2026 · PMC13356145 · PMID 40813935

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a negative trendno p-value reported

In CSF, irisin levels correlated with several biomarkers of AD pathology, including a positive correlation with CSF Aβ42 (indicative of lower central nervous system amyloid burden), a positive association with BDNF, and a negative trend with total tau (t-tau) [ 77 , 92 ].

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