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Intestinal Sirtuin 1 Controls Liver Regeneration via Regulating the Intestinal Farnesoid X Receptor/Fibroblast Growth Factor 15 Axis in Mice.

Cell Mol Gastroenterol Hepatol · 2026 · PMC13356667 · PMID 42173317

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We found that liver SIRT1 expression was marginally lower at 6 hours and 24 hours after PHx in SIRT intKO mice compared with WT mice, although these differences did not reach statistical significance ( Figure 2 A and B ).

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