Do Fasting GLP-1 and GIP Levels Predict the Initial Pharmacological Response to Semaglutide and Tirzepatide?

Diagnostics (Basel) · 2026 · PMC13360020 · PMID 42449760

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did not reach statistical significanceno p-value reported

Intermediate responders showed moderate improvements in waist circumference (mean 9.5 ± 2.8 cm for tirzepatide, 8.2 ± 2.5 cm for semaglutide) and HOMA-IR (mean reduction 2.1 ± 0.8 for tirzepatide, 1.8 ± 0.7 for semaglutide; both p < 0.01), while low responders exhibited minimal changes in both parameters that did not reach statistical significance. 3.5.

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