Diagnostic Significance of Ki-67, p53, and Mucin Glycoprotein Expression in Colorectal Serrated Lesions: Further Immunohistochemical Studies.

A p -value of < 0.05 was considered statistically significant for all tests, while values of < 0.001 were interpreted as highly significant. 3.

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The Linear-by-Linear Association test (Value = 14.221, p < 0.001) confirms a significant trend: As lesions progress toward more advanced histological stages, the proliferative zone progressively expands along the entire length of the crypt ( Figure 3 ). 3.4. p53 Expression in Serrated Lesions The immunohistochemical analysis of p53 expression revealed a highly statistically significant difference in staining patterns across the examined histological subtypes (Fisher’s Exact Test = 39.398; p < 0.001).

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