Retrieval-Based Evaluation of Cell Painting Feature Spaces Reveals Differences in the Preservation of Biologically Meaningful Phenotypic Similarity.

At the aggregated MOA level, 9 of 43 evaluable MOA classes were nominally significant in CellPaintSSL and OpenPhenom, corresponding to 20.9% of evaluable MOA classes, whereas 8 of 43 were nominally significant in uniDINO, corresponding to 18.6%.

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