However, when we restricted the analysis to the final 5 days of EEG monitoring and compared dose groups to vehicle, the differences in seizure activity and total ictal duration did not reach statistical significance at the predefined α, likely reflecting variability and reduced power due to mortality in the vehicle group.
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The small molecule simufilam dose-dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex.
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