Bidirectional Associations Between Circulating Polyunsaturated Fatty Acids and Female Reproductive Endocrine-Related Diseases: A Mendelian Randomization Study.

In nearly all comparisons, the MR-Egger intercept did not reach statistical significance, implying that unbalanced horizontal pleiotropy was not a major issue.

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The random-effects analysis was marginally significant as well, indicating that higher total omega-6 levels might contribute to an increased risk of endometriosis ( Figure 3A ).

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