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Co-Option and Conflict: The Deep Evolutionary History of ZP-Domain Proteins from ECMs to Species Barriers.

Int J Mol Sci · 2026 · PMC13361971 · PMID 42450137

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a clear trendno p-value reported
Comparative analyses across taxa reveal a clear trend: increasing complexity in gamete recognition systems correlates with progressive molecular specialization of the ZP, reflecting a shift from generalized protection to active mediation of fertilization.

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