Formal subgroup analysis did not demonstrate a statistically significant difference between monotherapy and combination therapy for MNSIE, MNSIQ, or sural nerve NCV (interaction p > 0.05) but demonstrated one for peroneal nerve NCV (interaction p = 0.039), although a numerical trend towards greater benefit with combination regimens was observed.
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Vitamin B Supplementation for Diabetic Peripheral Neuropathy: A Review and Meta-Analysis.
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Most of the interaction tests did not reach statistical significance ( Figure 8 and Figure 9 ), except peroneal nerve NCV ( Figure 9 ).