Diagnostic Value and Clinical Significance of Temporopolar White-Matter Hyperintensities in CADASIL and Sporadic Small-Vessel Disease.

6 , 24 In our cohort, the prevalence of temporopolar WMH showed a clear trend with the NOTCH3 variant—94.7% in HR-EGFr, 54.4% in MR-EGFr, and 33.3% in LR-EGFr—that mirrors the severity of vascular NOTCH3 aggregation in skin biopsies. 6 This pattern may help to explain the lower frequencies of temporopolar WMH reported in East Asian cohorts versus Caucasian populations, parti

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