Ultrasound-Guided Femoral Nerve Block with Esketamine Adjuvant for Postoperative Analgesia in Total Knee Arthroplasty-A Randomized, Double-Blind, Controlled Trial.

Drug Des Devel Ther · 2026 · PMC13367358 · PMID 42453929

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

Although the between-group difference in PONV incidence did not reach statistical significance, the lower rate observed in the esketamine group suggests a potential protective effect on gastrointestinal function mediated through opioid sparing—a finding that warrants confirmation in larger-scale studies.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.