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SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape.

J Clin Invest · 2026 · PMC13367968 · PMID 42228402

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However, the inverse correlation between SIRT2 expression and CD8 + T cell infiltration was modest and did not reach statistical significance by IHC ( Figure 10F ).

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