Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes.

CH mutational diversity at breast cancer diagnosis The most frequent co-occurring CH mutations involved DNMT3A , which was found to be co-mutated with TET2 ( n = 5; OR = 4.50, P = 0.14), YLPM1 ( n = 4; OR = 0.83; P = 0.73), and ZNF318 ( n = 3; OR = 1.20; P = 0.57) ( Figure 2C ), although this did not reach statistical significance.

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