A recent next-generation sequencing (NGS) study observed a high burden of pathogenic germline variants across cancer predisposition genes, particularly in MMR genes, in individuals with suspected familial or sporadic PAs, with a relative rate of 1.44 compared to the general population; however, this did not reach statistical significance ( 73 ).
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The germline landscape of pituitary adenomas: established and emerging predisposition genes.
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