Maternal RSV vaccination generates high-affinity antibodies that efficiently transfer to infants, providing enhanced passive immunity.

Highly significant differences ( p < 0.0001 ) were noted between vaccinated and unvaccinated groups for both maternal and cord blood samples against both viral strains.

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Isotype analysis revealed that the higher preF binding antibody titers in vaccinated individuals was primarily driven by IgG antibodies (2.3-fold higher), especially in cord blood samples (2.0-fold higher) that did not reach statistical significance (Fig. 2B ).

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