Modulation of the microbiota-lipid-brain axis by modified Chaihu-Longgu-Muli Decoction ameliorates chronic stress-induced depression.

Front Mol Neurosci · 2026 · PMC13372971 · PMID 42466320

Europe PMC DOI

hedged sentences

0.0030

closest p · 0.1× alpha

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boldest claim

The sentences

highly significantp = 0.003actually significant

Procrustes analysis using Bray–Curtis distances identified a highly significant global concordance between gut microbial community structure and serum metabolome profiles ( M 2 = 0.65, p = 0.003; Figure 6A ).

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a clear trendno p-value reported

Among beneficial genera, Lactobacillus and Romboutsia were significantly increased in the CH group compared with the MOD group (both * p < 0.05), while Dubosiella —a taxon markedly depleted by chronic stress—showed a clear trend toward recovery after mCLMD treatment.

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