Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.

J Transl Med · 2026 · PMC13374298 · PMID 42432754

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a strong trendno p-value reported

Physical fatigue showed a strong trend toward improvement but did not reach statistical significance (F 2.55,149 = 2.77, * p = 0.053; BKY FDR q = 0.0264) (Supplementary Fig. 6 A).

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