Epithelial-mesenchymal transition is associated with altered immune composition and cytotoxic function in triple-negative breast cancer.

Breast Cancer Res · 2026 · PMC13374390 · PMID 42464407

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To assess whether these changes followed a significant trend along the EMT spectrum, we performed a regression analysis treating EMT state as an ordered variable, which revealed a significant decrease in the proportion of Gzmb+ CD8+ T cells ( P = 0.032) and a significant increase in the proportion of Tregs ( P = 0.044) along the EMT spectrum.

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