The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve.

Blastocyst formation followed similar trends but did not reach statistical significance ( Figure 6F ), suggesting that the primary defect lies in oocyte quality rather than post-fertilization development, a pattern also seen in human obesity-related subfertility. 105 , 106 These findings show that dietary fiber protects against high-fat diet-induced impairments in oocyte quality and early embryo competence by normalizing transcriptional pathways involved in inflammation, mitochondrial function, and oxidative stress response.

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