Spatial characterization of skin lesions in discoid and systemic lupus erythematosus.

Although a similar positive trend was observed between total dermal immune cell density and lesion duration, this association did not reach statistical significance ( R = 0.56, P = 0.075) (Supplementary Fig. 9a ).

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We also detected a decreasing trend in monocyte-like macrophages (Mac_Mono), C1Q-related macrophages (Mac_C1Q), resident tissue macrophages (Mac_RT), and IFN macrophages (Mac_IFN) in TLS regions compared with non-TLS regions, but no significant differences in the distributions of plasma cells or other macrophage/DC subsets were found (Supplementary Fig. 10b, c ).

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