There is a clear trend of AF, when modeling the interaction between the whole RNF5 protein and EphA2-Sam, to favor the RNF5 RING as an EphA2-Sam binding partner rather than the TM2 region, which, according instead to the experimental evidence, should represent the true interaction site.
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The Interaction between the Tyrosine Kinase Receptor EphA2 and RNF5: Structural Insights from an <i>In Silico</i> Approach.
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