Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7.

Adv Sci (Weinh) · 2026 · PMC13379251 · PMID 42467931

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We further observed that PE7‐treated neuronal cultures showed a trend toward attenuation of the H2O2‐induced increase in cleaved caspase‐3 (c‐Caspase‐3)‐positive and Tuj1‐positive cells, without reaching statistical significance (Figure 2e,f ).

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