Estimated glomerular filtration rate discordance and cardiopulmonary morbidity in sickle cell disease.

23 , 33 In addition, we observed a significant trend wherein eGFR discordance became progressively more negative across descending categories of baseline creatinine eGFR ( P for trend = .01; Figure 4 ).

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Hydroxyurea showed a nonsignificant trend toward attenuation.

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