Donor-Acceptor Separation Augments Temperature Dependence of Kinetic Isotope Effects in NADH Model Hydride Transfer Reactions: Mimicking Enzyme versus Mutant Dynamics.

This conclusion establishes an important trend that the proton-transfer Δ E a values in reactions (2) may be comparable to that of the Cl 4 Q reaction and both remain intermediate between those observed for the hydride-transfer reactions in (1) and the proton-transfer steps in (3).

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