Global burden of breast cancer and its association with red meat consumption: spatiotemporal trends, projections, and triangulation of evidence.

In the univariable MR analysis (Supplementary Table S1), after excluding outliers (rs1421085, rs62396185, rs12247907, and rs7791463 for beef; rs11211124 for pork; rs9379832 and rs35797675 for lamb) using the MR-PRESSO method, the inverse-variance weighted (IVW) approach revealed a nominally significant association between genetically predicted beef intake and breast cancer risk (OR = 1.511, 95% CI: 1.010–2.260, P = 0.044), with no evidence of heterogeneity or horizontal pleiotropy.

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The projections revealed that while male BC DALYs and mortality rates exhibited an increasing trend from 1990 to 2010, they are predicted to demonstrate a sustained decline through 2030.

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Wald test results demonstrated highly significant age effects on incidence ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:{\chi\:}^{2}$$\end{document}

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