Modeling Alzheimer's disease with brain organoids: mechanisms, applications, and future directions.

Front Cell Dev Biol · 2026 · PMC13388760 · PMID 42488555

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nominally significantno p-value reported

In the prespecified mild cognitive impairment subgroup, valiltramiprosate demonstrated nominally significant clinical benefits on ADAS-Cog13, along with positive trends on functional outcomes ( Abushakra et al., 2025 ; Hey et al., 2025 ). 5.6.3 Non-genetic and environmental factors in sAD Han et al.

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