a negative trendp value = 0.057
Using the genes that contributed most to the enrichment of this upregulated gene set ( n = 48 genes), we built the first principal component (PC1) of their VAT bulk expression and identified a negative trend (rho = −0.242, p value = 0.057) between PC1 of the VAT bulk expression and the adipocyte diameter in RYSA (Supplementary Note 1.7 , Supplementary Data 43 ).