Cross-species transcriptomic analysis of rodent model fidelity to human mesial temporal lobe epilepsy.

Nat Commun · 2026 · PMC13392440 · PMID 42230582

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a positive trendno p-value reported

In contrast, GO terms related to neuroinflammation, neuronal death, neurogenesis, and gliogenesis showed a positive trend in MTLE.

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a negative trendno p-value reported

Most GO terms associated with neurotransmission, ion channels, and synaptic plasticity, except for the kainate receptor GO term, exhibited a negative trend in MTLE.

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