Postoperative bisphosphonate therapy is associated with lower prosthesis-related complications after total or reverse shoulder arthroplasty in osteoporotic patients: a TriNetX-based cohort study.

BMC Musculoskelet Disord · 2026 · PMC13393243 · PMID 42177517

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0.0900

closest p · 1.8× alpha

0.0900

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did not reach statistical significanceP = 0.09so close (0.05 < p ≤ 0.1)

Regarding comorbid conditions, bisphosphonate use was associated with lower complication risk in patients with T2DM (HR, 0.70; 95% CI, 0.52–0.93; P = 0.012) and RA (HR, 0.68; 95% CI, 0.51–0.90; P = 0.007), whereas the reduction in patients with COPD did not reach statistical significance (HR, 0.76; 95% CI, 0.55–1.05; P = 0.09) (Table 3 ).

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