Exploring brain-gut interaction mechanisms in Transcutaneous auricular Vagus Nerve stimulation for Major Depressive Disorder.

BMC Psychiatry · 2026 · PMC13393621 · PMID 42487113

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0.1250

closest p · 2.5× alpha

0.1250

boldest claim

The sentences

did not reach statistical significanceP = 0.125not close (p > 0.1)

Repeated measures ANOVA revealed significant group × time interaction effects for HAMD-17 ( F (1, 78) = 12.51, P = 0.0007) and HAMA-14 ( F (1, 78) = 6.62, P = 0.012) scores, while the interaction for GSRS did not reach statistical significance ( F (1, 78) = 2.40, P = 0.125).

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an increasing trendno p-value reported

However, post-intervention comparisons between the two groups, as well as comparisons within the taVNS group pre- and post-intervention, indicated an increasing trend in sample distances.

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