Clinical Significance of PD-L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy.

Ann Gastroenterol Surg · 2026 · PMC13394168 · PMID 42495682

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a nonsignificant trendno p-value reported

4 Discussion In this study, higher PNI values were significantly associated with a favorable response to ICI therapy, whereas CRP levels showed only a nonsignificant trend toward lower values in responders.

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did not reach statistical significanceno p-value reported

As summarized in Tables 3 and 4 , patients with downregulated HLA‐A/B/C expression had higher median hemoglobin levels; their PNI values also tended to be higher, but this difference did not reach statistical significance.

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