Survival analysis Kaplan–Meier survival analysis of the 29 hub genes using the UALCAN module (TCGA-ESCA) showed that higher expression of ATG4A, GABARAPL2, and GAPDH was significantly associated with poorer overall survival (log-rank p < 0.05), whereas the remaining hubs did not reach statistical significance under the same settings (Fig. 4 ; Table S4 of the Supplementary material).
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Autophagy-centered gene networks reveal prognostic biomarkers and therapeutic targets in esophageal cancer.
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