KRAS<sup>G12V/A146T</sup> mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.

Cell Mol Biol Lett · 2026 · PMC13397665 · PMID 42210090

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showed a trendno p-value reported

Across assays, KRAS G12V showed higher NHEJ output and stronger recruitment of NHEJ factors than KRAS A146T , whereas KRAS A146T showed a trend toward higher HR output, consistent with codon-dependent differences in pathway engagement.

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KRAS&lt;sup&gt;G12V/A146T&lt;/sup&gt; mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.

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KRAS<sup>G12V/A146T</sup> mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.