Comparative efficacy and safety of extended versus continuous infusion of beta-lactam antibiotics for severe infection: a network meta-analysis of randomized trials.

Crit Care · 2026 · PMC13397700 · PMID 42323608

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a strong trendno p-value reported

In the meropenem subgroup, EI showed a strong trend toward mortality reduction (OR 0.48, 95% CI 0.19–1.24) and ranked highest (SUCRA 89.1%), while in the piperacillin/tazobactam subgroup, CI was associated with the greatest mortality reduction (OR 0.22, 95% CI 0.03–1.18; SUCRA 95.1%) [ 12 , 77 ].

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