Hemostatic safety profile of estetrol vs. ethinylestradiol in oral contraceptives: a systematic review and meta-analysis.

Rev Bras Ginecol Obstet · 2026 · PMC13399374 · PMID 42500171

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0.3000

closest p · 6.0× alpha

0.3000

boldest claim

The sentences

did not reach statistical significancep=0.30not close (p > 0.1)

Trends favoring E4/DRSP were observed for antithrombin activity, although these did not reach statistical significance (MD = 1.80; 95% CI -1.58 to 5.17; p=0.30; I 2 =35%) ( Figure 3 ).

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