Toward generalizable prediction of cancer signal using a cell-free DNA language model.

Additionally, there was a clear trend of increasing model scores from noncancer, to post-surgery, to pre-surgery samples ( Figures 2 G and 2H).

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The model learns to weigh the importance of these relationships, for instance, recognizing that a specific motif is highly significant if it appears at the fragment terminus but irrelevant if found in the center.

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