Modelling dose and dose-averaged linear energy transfer to predict high-grade temporal lobe necrosis following skull-base proton therapy.

For each dose bins, delta LET d values were reported in Figure S2 describing a decreasing trend in delta LET d with increasing doses.

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In particular, a significant trend of decreasing differences between median LET d in necrotic and healthy brain voxels with increasing matched doses was observed (Figure S2 ).

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